Pakistan were in a strong position to win the second Test and level the series after removing both England openers on a tricky Multan pitch on Thursday with spinner Sajid Khan their hero.
The hosts set England a daunting target of 297 before Sajid dismissed Ben Duckett and fellow spinner Noman Ali had Zak Crawley to leave England on 36-2 after Day Three.
Ollie Pope and Joe Root were unbeaten on 21 and 12 respectively with 261 still needed for victory and two days left.
Before that, middle-order batsman Salman Agha scored 63 and together with Sajid (22) lifted the home side from a precarious 134-5 with a ninth-wicket stand of 65, taking Pakistan to 221 in their second innings.
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